2000
Fu, K., Klibanov, A., Langer, R. “Protein stability in controlled release systems”, Nature Biotech.; 18: 24-25, 2000.
Kost, J., Mitragotri, S., Gabbay, R., Pishko, M., Langer, R. “Transdermal monitoring of glucose and other analytes using ultrasound”, Nature Medicine; 6: 347-350, 2000.
Kim, B., Langer, R., Hrkach, J. “Biodegradable photo-crosslinked poly (ether-ester) networks for lubricious coatings”, Biomaterials; 21: 259-265, 2000.
Langer, R. “Tissue engineering”, Mol. Therapy; 1:12-15, 2000.
Mitragotri, S., Farrell, J., Tang, H., Terahara, T., Kost, J., Langer, R. “Determination of the threshold energy for ultrasound-induced transdermal drug delivery”, Journal of Controlled Release; 63: 41-52, 2000.
Tobio, M., Schwendeman, S., Guo, Y., McIver, J., Langer, R., Alonoso, M. “Improved immunogenicity of a core-coated tetanus toxoid delivery system”, Vaccine; 18: 618-622, 2000.
Fu, K., Pack, D., Klibanov, A., Langer, R. “Visual evidence of acidic environment within degrading PLGA microspheres”, Pharmaceutical Research; 17: 100-106 , 2000.
Elisseeff, J., McIntosh, W., Anseth, K., Riley, S., Ragan, P., Langer, R. “Potoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks”, Journal of Biomedical Materials Research; 51: 164-171, 2000.
Langer, R. “Biomaterials, Status, Challenges, and Perspectives”, AIChE Journal; 46: 1286-1289, 2000.
Shastri, V., Martin, I., Langer, R. “Macroporous polymer foams by hydrocarbon templating”, Proc. Nat. Acad. Sci.; 97: 1970-1975, 2000.
Santini, J., Richards, A., Scheidt, R., Cima, M., Langer, R. “Microchips as controlled release devices”, Angewandte Chemie; 39: 2396-2407, 2000.
Santini, J., Richards, A., Scheidt, R., Cima, M., Langer, R. “Microchip technology in drug delivery”, Annals of Medicine; 32: 377-379, 2000.
Mitragotri, S., Coleman, M., Kost, J., Langer, R. “An analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels”, J. Appl. Physiol.; 89: 961-966, 2000.
Lu, L., Peter, S., Lyman, M., Lai, H., Leite, S., Tamada, J., Vacanti, J., Langer, R., Mikos, A. “In vitro degradation of porous poly(L-lactic acid) foams”, Biomaterials; 21: 1595-1605, 2000.
Lu, L., Peter, S., Lyman, M., Lai, H., Leite, S., Tamada, J., Uyama, S., Vacanti, J., Langer, R., Mikos, A. “In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams”, Biomaterials; 21: 1837-1845, 2000.
Langer, R. “Biomaterials in drug delivery and tissue engineering: one laboratory’s experience”, Accounts of Chemical Research; 33: 94-101, 2000.
Langer, R. “New tissues for old”, Chemistry in Britain; 36: 32-34, 2000.
Mitragotri, S., Kost, J., Langer, R. “Enhancement of transdermal transport through a synergistic effect of ultrasound and other enhancers, in “, Handbook of Pharm. Cont. Rel. Tech.; Wise, D. ed., Marcel Dekker, 607-616, 2000.
Mitragotri, S., Langer, R., Kost, J. “Ultrasound for modulation of skin transport properties, in “, Biomaterials Engineering and Devices: Human Applications; Wise, D., ed., Trantolo, D., Altobeli, D., Yazemski, M., Wnek, G., and Gresser, J. Marcel Dekker, 843-854, 2000.
Mitragotri, S., Ray, D., Farrell, J., Tang, H., Yu, B., Kost, J., Blankschtein, D., Langer, R. “Synergistic effect of low-frequency ultrasound and Sodium Lauryl Sulfate on transdermal transport”, Journal of Pharmaceutical Sciences; 89, 892-900, 2000.
Mitragotri, S., Kost, J., Langer, R. “Non-invasive drug delivery and diagnostics using low-frequency sonophoresis”, Recent Advances and Research Updates in Medicine, 1, 43-48, 2000.
Mitragotri, S., Coleman, M., Kost, J., Langer, R. “Transdermal Extraction of Analytes Using Ultrasound”, Pharmaceutical Research; 17, 466-470, 2000.
Schaefer, D., Martin, I., Shastri, P., Padera, R., Langer, R., Freed, L., Vunjak-Novakovic” In vitro generation of osteochondral composites”, Biomaterials; 21: 2599-2606, 2000.
Lynn, D., Langer, R. “Degradable poly(b-amino esters): synthesis, characterization, and self-assembly with plasmid DNA”, J. Am. Chem. Soc.; 122: 10761-10768, 2000.
Chen, T., Langer, R., Weaver, J. “Transdermal Drug Delivery by Skin Electroporation, in”, Handbook of Pharm. Cont. Rel. Tech. Wise, D. ed., Marcel Dekker, 597-605, 2000.
Langer, R. “Tissue engineering: Status and challenges”, The Journal of Regen. Med.; 1: 5-6, 2000.
Mitragotri, S., Coleman, M., Kost, J., Langer, R. “Non-invasive blood analyte extraction using ultrasound”, Pharmaceutical Research; 17: 467-470, 2000.
Kohane, D., Lipp, M., Kinney, R., Lotan, N., Langer, R. “Sciatic Nerve Blockade with Lipid-Protein-Sugar Particles Containing Bupivacaine”, Pharmaceutical Research; 17: 1243-1249, 2000.
Patel, N., Bhandari, R., Shakesheff, K.M., Cannizzaro, S., Davies, M., Langer, R., Roberts, C., Tendler, S., Williams, P. “Printing Patterns for Biospecifically Adsorbed Proteins”, Journal of Biomaterials Science Polymer Edition; 11: 319-331, 2000.
1999
Moses, M., Weiderschain, D., Wu, I., Fernandez, C., Ghazizadeh, V., Lane, W., Flynn, E., Sytkowski, A., Tao, T., Langer, R. “Troponin I is present in human cartilage and inhibits angiogenesis”, PNAS; 96: 2645-2650, 1999.
Stading, M., Langer, R. “Mechanical shear properties of cell-polymer cartilage constructs”, Tissue Engineering; 5: 3, 241-250, 1999.
Chen, T., Langer, R., Weaver, J. “Charged microbeads are not transported across the human stratum corneum in vitro by short high-voltage pulses”, Bioelectrochemistry and Bioenergetics; 48: 181-192, 1999.
Ben-Jebria, A., Chen, D., Eskew, M., Vanbever, R., Langer, R., Edwards, D. “Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs”, Pharmaceutical Research; 16: 555-561, 1999.
Ma, P., Langer, R. “Morphology and mechanical function of long-term in vitro engineered cartilage”, Journal of Biomedical Matericals Research; 44: 217-221, 1999.
Caponetti, G., Hrkach, J., Kriwet, B., Poh, M., Lotan, N., Colombo, P., Langer, R. “Microparticles of novel poly(lactic acid-co-amino acid) graft copolymers: preparation and characterization”, Journal of Pharmaceutical Science; 88:1, 136-141, 1999.
Ando, S., Putnam, D., Pack, D., Langer, R. “PLGA microspheres containing plasmid DNA: preservation of supercoiled-DNA via cryopreparation and carbohydrate stabilization”, Journal of Pharmaceutical Science; 88:1, 126-130, 1999.
Santini, J., Cima, M., Langer, R. “A Controlled-release Microchip”, Nature; 397: 335-338, 1999.
Ameer, G., Grovender, E., Obradovic, B., Cooney, C., Langer, R. “RTD Analysis of a novel taylor-couette flow device for blood detoxification”, AIChE Journal; 45: 3, 633-638, 1999.
Zewert, T., Pliquett, U., Vanbever, R., Langer, R., Weaver, J. “Creation of transdermal pathways fro macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule”, Bioelectrochem. Bioenerget; 49: 11-20, 1999.
Ameer, G.A., Harmon, W., Sasisekharan, R., Langer, R. “Investigation of a whole blood fluidized bed taylor-couette flow device for enzymatic heparin neutralization”, Biotechnology and Bioengineering; 62: 5, 602-608, 1999.
Kohane, D., Kuang, Y., Nu, T., Langer, R., Strichartz, G., Berde, C. “Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 soldium channel blockers”, Anesthesiology; 90: 2, 524-534, 1999.
Pack, D., Putnam, D., Langer, R. “Design of imidazole-containing endosomolytic biopolymers for gene delivery”, Biotechnology and Bioengineering; 67: 217-223, 1999.
Elisseff, K., Anseth, D., Sims, W., McIntosh, W., Randolph, M., Langer, R. “Transdermal photopolymerization for minimally invasive implantation”, PNAS; 96: 3104-3107, 1999.
Niklason, L., Gao, J., Abbot, W., Hirschi, K., Houser, S., Marini, R., Langer, R. “Functional arteries grown in vitro”, Science; 284: 489-493, 1999.
Anseth, K., Shastri, V., Langer, R. “Photopolymerizable degradable polyanhydrides with osteocompatibility”, Nature Biotechnology; 17: 156-159, 1999.
Vunjak-Novakovic, G., Martin, I., Obradovic, B., Treppo, S., Grodzinsky, A., Langer, R., Freed, L. “Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue engineered cartilage”, Journal of Orthopaedic Research; 17: 1, 130-138, 1999.
Sinisterra, R., Shastri, V., Najjar, R., Langer, R. “Encapsulation and release of rhodium (II) citrate and its association complex with hydroxypropyl-B-cyclodextrin from biodegradable polymer Microspheres”, Journal of Pharmaceutical Science; 88:5, 574-576, 1999.
Ameer, G., Barabino, G., Sasisekharan, R., Harmon, W., Cooney, C., Langer, R. “Ex vivo evaluation of a novel taylor-couette flow, immobilized heparinase I device for clinical application”, Proc. Nat. Acad. Sci.; 96: 2350-2355, 1999.
Fu, K., Griebenow, K., Hsieh, L., Klibanov, A., Langer, R. “FTIR characterization of the secondary structure of proteins encapsulated within PLGA mircrospheres”, Journal of Controlled Release; 58: 3, 357-366, 1999.
Zelikin, A., Shastri, V., Langer, R. “Facile synthesis of 3-alkylpyrroles”, Journal of Organic Chemistry; 64: 9, 3379-3380, 1999.
Langer, R., Vacanti, J. “Tissue engineering: the challenges ahead”, Scientific American; 280: 62-65, 1999.
Putnam, D., Langer, R. “Poly(4-hydroxy-L-proline ester): low-temperature polycondensation and plasmid DNA complexation”, Macromolecules; 32: 11, 3658-3662, 1999.
Shakesheff, K., Davies, M., Langer, R. “Surface characterization methods”, J. Biomat. Sci.; 9: 507-518, 1999.
Attawia, M., Herbert, K., Uhrich, K., Langer, R., Laurencin, C. “Proliferation, morphology, and protein expression by osteoblasts cultured on poly(anhydride-co-imides)”, Journal of Biomedical Materials Research; 48: 322-327, 1999.
Kost, J., Mitragotri, S., Langer, R. “Phonophoresis, in “, Percutaneous Absorption: Drugs-Cosmetics-Mechanisms-Method, edited by Robert L. Bronaugh, Howard I. Maibach, Vol. 97, 3rd Edition, p. 615-631, 1999.
Dillow, A., Dehghani, F., Hrkach, J., Foster, N., Langer, R. “Bacterial inactivation by using near- and supercritical carbon dioxide”, Proceedings of the National Academy of Sciences; 96: 10344-10348, 1999.
Elisseeff, J., Winnette, M., Anseth, K., Langer R. “Cogelation of hydrolyzable cross-linkers and poly(ethylene oxide) dimethacrylate and their use as controlled release vehicles, in”, Intelligent Mat. for Cont, Rel: ACS Symp. Ser. 728: 1-13, Dinh, S., DeNuzzio, J., Comfort, A., eds., 1999.
Vanbever, R., Ben-Jebria, A., Mintzes, J., Langer, R., Edwards, D. “Sustained release of insulin from insoluble inhaled particles”, Drug Delivery Research48: 178-185, 1999.
Vacanti, J., Langer, R. “Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation”, Lancet; 354: 32-34, 1999.
Carrier, R., Papadaki, M., Rupnick, M., Schoem, F.J., Bursac, N., Langer, R., Freed, L., Vunjak-Novakovic, G. “Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization”, Biotechnology & Bioengineering; 64: 580-589, 1999.
Vanbever, R., Mintzes, J., Wang, J., Nice, J., Chen, D., Batycky, R., Langer, R., Edwards, D. “Formulation and physical characterization of large porous particles for inhalation”, Pharmaceutical Research; 16: 1735-1742, 1999.
Weaver, J., Langer, R. “Electrochemical creation of large aqueous pathways: an approach to transdermal drug delivery”, Progress in Dermatology 33: 1-10, 1999.
Mitragotri, S., Johnson, M., Blankschtein, D., Langer, R. “A theoretical analysis of solute partitioning, diffusion, and permeation across lipid bilayers”, Biophysical Journal; 77: 1268-1283, 1999.
Langer, R. “Selected advances in drug delivery and tissue engineering”, Journal of Controlled Release; 62: 7-11, 1999.
Uhrich, K., Cannizzaro, S., Langer, R., Shakesheff, K. “Polymeric systems for controlled drug release”, Chemical Reviews; 99: 3181-3198, 1999.
Ameer, G., Raghavan, S., Sassisekharan, R., Cooney, C., Harmon, W., Langer, R. “Regional heparinization via Simultaneous separation and reaction in a novel taylor-couette flow device”, Biotechnology and Bioengineering; 63: 618-624, 1999.
Papadaki, M., Langer, R. “Cardiomyoplasty: Cellular tissue engineering approaches”, Basic and Appl. Myology; 9: 151-159, 1999.
Stading, M., Langer, R. “Rheological properties and microstructure of tissue engineered cartilage”, The Wiley Poly. Network. Group Rev. Series 32: 405-414, 1999.
Elisseeff, J., Anseth, K., Sims, D., McIntosh, W., Randolph, M., Yaremchuk, M., Langer, R. “Transdermal Photopolymerization of PEO-based injectable hydrogels for tissue engineered cartilage”, Plastic and Reconstructive Surgery; 104: 1014-1022, 1999.
Weaver, J., Pliquett, U., Zewart, T., Vanbever, R., Herndon, T., Gowrishankar, T., Chen, T., Prausnitz, M., Vaughan, T., Chizmadzhev, Y., Preat, V., Langer, R. “Recent advances in skin electroporation: mechanism and efficacy. In”, Elec. And Magnetism in Bio. And Med. F. Bersani, ed. New York: Plenum Press, 149-152, 1999.
Patel, N., Sanders, G.H.W., Shakesheff, K.M, Cannizzaro, S.M., Davies, M.C., Langer, R., Roberts, C.J., Tendler, S.J.B., Williams, P.M. “Atomic force microscopy analysis of highly defined proteins formed by microfluidic networks”, Langmuir; 15: 7252-7257, 1999.
Shakesheff, K.M, Davies, M.C., Langer, R. “The use of XPS in surfactant surface analysis”, Surfactant Science Series, 87: 143-172, 1999.
Black, R., Hartshorne, M., Davies, M., Roberts, C., Tendler, S., Williams, P., Shakesheff, K., Cannizzaro, S., Kim, I., Langer, R. “Surface engineering and surface analysis of a biodegradable polymer with biotinylated end-groups”, Langmuir; 15: 3157-3161, 1999.
Shum-Tim, D., Stock, U., Hrkach, J., Shinoka, T., Lien, J., Moses, M., Stamp, A., Taylor, G., Moran, A., Landis, W., Langer, R., Vacanti, J., Mayer, J.E. “Tissue engineering of autologous aorta using a new biodegradable polymer”, Annals of Thoracic Surgery; 68: 2298-304, 1999.
Mitragotri, S., Johnson, M., Blankschtein, D., Langer, R. “On the origin of size selectivity of biological membranes to non-electrolytes”, Biophysical Journal; 77, 1268-1283, 1999.
1998
Gao, J., Niklason, L., Zhao, X., Langer, R. “Surface modification of polyanhydrides microsphere”, Journal of Pharmaceutical Science; 87: 2, 246-248, 1998.
Evora, C., Soriano, I., Rogers, R., Hanes, J., Shakesheff, K., Langer, R. “Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: The effect of 1, 2-dipalmitoylphosphatidylcholine”, Journal of Controlled Release; 51: 143-152, 1998.
Langer, R. “Drug delivery and targeting”, Nature; 392 (Supp): 5-10, 1998.
Shinoka, T., Shum-Tim, D., Ma, P., Tanel, R., Isogai, N., Langer, R., Vacanti, J., Mayer, J.E. “Creation of viable pulmonary artery autografts through tissue engineering”, J. Thor. and Cardiovasc. Surg; 115:3, 536-546, 1998.
Vunjak-Novakovic G., Obradovic B., Bursac P., Martin, I., Langer R. Freed L. “Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering”, Biotechnol. Prog.; 14: 193-202, 1998.
Freed, L., Hollander, A., Martin, I., Barry, J., Langer, R., Vunjak-Novakovic, G. “Chondrogenesis in a cell-polymer-bioreactor system”, Exper. Cell Res.; 240: 58-65, 1998.
Pollock, J., Kluth, D., Cusick, R., Lee, H., Utsunomiya, H., Ma, P., Langer, R., Broelsch, C., Vacanti, J. “Formation of spheroidal aggregates of hepatocytes on biodegradable polymers under countinuous-flow bioreactor conditions”, European Journal of Pediatr. Surg.; Vol. 8: 195-199, 1998.
Hanes, J., Chiba, M., Langer, R. “Degradation of porous poly(anydride-co-imide) microspheres and implications for controlled macromolecule delivery”, Biomaterials; 19: 163-172, 1998.
Cannizzaro, S., Padera, R., Langer, R., Rogers, R., Black, F., Davies, M., Tendler, S., Shakesheff, K. “A novel biotinylated degradable polymer for cell-interactive applications”, Biotechnology and Bioengineering; 58: 529-535, 1998.
Kohane, D., Yieh, J., Lu, N., Langer, R., Strichartz, G., Berde, C. “A re-examination of tetrodotoxin for prolonged duration local anesthesia”, Anesthesiology; 89: 119-131, 1998.
Schwendeman, S., Tobio, M., Joworowicz, M., Alonso, J., Langer, R. “New strategies for the microencapsulation of tetanus vaccine”, J. Microencapsulation; 15: 299-318, 1998.
Costantino, J., Schwendeman, S., Langer, R., Klibanov, A. “Deterioration of lyophilized pharmaceutical proteins”, Biochem.; 63: 357-363, 1998.
Ibim, S., Uhrich, K., Bronson, R., El-Amin, S.F., Langer, R., Laurencin, C. “Poly(anhydride-co-imides): in vivo biocompatibility in a rat model”, Biomaterials; 19: 944-951, 1998.
Hadlock, T., Elisseeff, J., Langer, R., Vacanti, J., Cheney, M. “A tissue-engineered conduit for facial nerve repair”, Arch. Otolaryngol Head Neck Surg; 124(10): 1081-1086, 1998.
Shakesheff, K., Cannizzaro, S., Langer, R. “Creating biomimetic micro-environments with synthetic polymer-peptide hybrid molecules”, Journal of Biomaterials Science-Polymer Edition; 9: 507-518, 1998.
Shastri, V., Padera, R., Tarcha, P., Langer, R. “Biocompatibility of Orthocure TM Photopolymerizable Anahydride Networks”, Journal of Biomedical Materials Research; 530: 93-98, 1998.
Marler, J., Upton, J., Langer, R., Vacanti, J. “Transplantation of cells in matrices for tissue regeneration”, Adv. Drug Del. Rev.; 33: 165-182, 1998.
Riesle, J., Hollander, A., Langer, R., Freed, L., Vunjak-Novakovic, G. “Collagen in tissue-engineered cartilage: types, structure, and crosslinks”, J. Cell. Biochem.; 71: 313-327, 1998.
Chen, H., Langer, R. “Oral particulate delivery: status and future trends”, Adv. Drug Del; 34, 339-350, 1998.
Gao, J., Niklason, L., Langer, R. “Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells”, Journal of Biomedical Materials Research; 42: 417-424, 1998.
Ma, P., Langer, R. “Fabrication of bioegradable polymer foams for cell transplantation and tissue engineering”, Methods in Molecular Medicine 18: 47-56, J. Morgan and M.L. Yarmush (eds), Humana Press, Totowa, NJ, 1998.
Ibim S., Uhrich K., Attawia M, Shastri V., El-Amin S., Bronson R., Langer R., Laurencin CT”Preliminary in vivo report on the osteocompatibility of poly(anaydride-co-imides) evaluated in a tibial model”, Journal of Biomedical Materials Research; 43: 374-379, 1998.
Tobio, M., Gref, R., Sanchez, A., Langer, R., Alonso, M. “Stealth PLA-PEG nanoparticles as protein carriers for nasal administration”, Pharmaceutical Research; 15: 2, 270-275, 1998.
Chen, T., Langer, R., Weaver, J. “Skin electroporation causes molecular transport across the stratum corneum through localized transport regions”, Journal of Investigative Dermatology; 3: 159-165, 1998.
Patel, N., Padera, R., Sanders, G., Cannizzaro, S., Davies, M., Langer, R., Roberts, C., Tendler, S., Williams, P., Shakesheff, K. “Spatially controlled cell engineering on biodegradable polymer surfaces”, FASEB Journal; 12: 1447-1457, 1998.
Chen, T., Segall, E., Langer, R., Weaver, J. “Skin electroporation: rapid measurements of the transdermal voltage and the flux of four fluorescent molecules show a transition to large fluxes near 50v”, Journal of Pharmaceutical Science; 87: 1368-1374, 1998.
Uhrich, K., Ibim, S., Larrier, D., Langer, R., Laurencin, C. “Chemical changes during in vivo degradation of poly(anhydride-imide) matrices”, Biomaterials; 19, 2045-2050, 1998.
Riesle, J., Hollander, A., Langer, R., Freed, L., Vunjak-Novakovic, G. “Collagen in tissue-engineered cartilage: types, structure and crosslinks”, Journal of Cellular Biochemistry71, 313-327, 1998.
1997
Costantino, H., Liauw, S., Mitragotri, S. Langer, R., Klibanov, A., Sluzky, V. “The pharmaceutical development of insulin: Historical perspectives and future directions ACS Symposium Series”, Therapeutic Protein and Peptide Form. and Del. Shahrokh, Z., Sluzky, V., Cleland, J.., Shire, S., Randolph, T., Eds., American Chemical Society, Washington, DC, 29-66, 1997.
Peter, S., Yaszemski, M., Suggs, L., Payne, R., Langer, R., Hayes, W., Unroe, M., Alemany, L., Engel, P., Mikos, A. “Characterization of partially saturated poly(propylene fumarate) for orthopaedic application”, J. Biomater. Sci.; 8: 893-904, 1997.
Langer, R. “Tissue engineering: A new field and its challenges”, Pharmaceutical Research; 14, 840-841, 1997.
Chaignaud B., Langer, R., Vacanti, J. “History of tissue engineering with synthetic scaffolds”, Synth. Biodegradable Poly. Scaffolds, 1-14, Atala, A., Langer, R., Mooney, D., Vacanti, J., eds., Boston: Birkhauser, 1997.
Kim, T., Lee, H., Utsunomiya, H., Ma, P., Langer, R., Schmidt, E., Vacanti, J. “Enhanced survival of transgenic hepocytes expressing hepatocyte growth factor in heptocyte tissue engineering”, Transplant Prot. 29, 858-860, 1997.
Chen, H., Langer, R. “Magnetically-responsive liposomes as potential oral delivery vehicles”, Pharmaceutical Research; 14, 537-50, 1997.
Costantino, H., Griebenow, K., Langer, R., A. Klibanov”On the pH memory of lyophilized compounds containing protein functional groups”, Biotechnology and Bioengineering; 53: 345-348, 1997.
Uhrich, K., Thomas, T., Laurencin, C., Langer, R. “In vitro degradation characteristics of poly(anhydride imides) containing trimellitylimidoglycine”, Journal of Applied Polymer Science; 63: 1401-1411, 1997.
Costantino, H., Shieh, L., Klibanov, A., Langer, R. “Heterogeneity of serum albumin samples with respect to solid-state aggregation via thiol-disulfide interchange-Implications for sustained release from polymers”, Journal of Controlled Release; 44: 255-261, 1997.
Shakesheff, K., Evora, C., Soriano, M., Langer, R. “The adsorption of poly(vinyl alcohol) to biodegradable microparticles studied by x-ray photoelectron spectroscopy (XPS)”, Journal of Colloid and Interface Science; 185: 538-547, 1997.
Ernst, S., Garro, O., Winkler, S., Venkataraman, G., Langer, R., Cooney, L., Sasisekharan, R. “Process simulation for recombinant protein production: Cost estimation and sensitivity analysis for heparinase I expressed in Escherichia coli”, Biotechnology and Bioengineering; 53: 575-582, 1997.
Cook, A., Hrkach, J., Gao, N., Johnson, I., Pajvani, U., Cannizzaro, S., Langer, R. “Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial”, Journal of Biomedical Materials Research; 35: 513-523, 1997.
Mader, K., Bacic, G., Domb, A., Elamalak, O, Langer, R., Swartz, H. “Noninvasive in vivo monitoring of drug release and polymer erosion from biodegradable polymers by EPR spectroscopy and NMR imaging”, Journal of Pharmaceutical Science; 86: 126-134, 1997.
Narasimhan, B., Langer, R. “Zero-order release of micro- and macromolecules from polymeric devices: The role of the burst effect”, Journal of Controlled Release; 47: 13-20, 1997.
Peracchia, M., Gref, R., Minamintake, Y., Domb, A, Lotan, N., Langer, R. “PEG-coated nanospheres form amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics”, Journal of Controlled Release; 46: 223-231, 1997.
Elisseeff, J. Anseth, K, Langer, R., Hrkach, J. “Synthesis and characterization of photocrosslinked polymers based on poly(L-lactic acid-co-L-aspartic acid)”, Macromolecules; 30: 2182-2184, 1997.
Edwards, D., Hanes, J., Caponetti, G., Hrkach, J., Ben-Jebria, A, Eskew, M., Mintzes, J. Deaver, D., Lotan, N., Langer, R. “Large porous aerosols for pulmonary drug delivery”, Science; 276: 1868-1871, 1997.
Chiba, M., Hanes, J., Langer, R. “Controlled Protein Delivery from Biodegradable Tyrosine-Containing Poly(anhydride-co-imide) Microspheres”, Biomaterials; 18: 893-901, 1997.
Zund, G., Breuer, C., Shinoka, T., Ma, P., Langer, R., Mayer J., Vacanti, J. “A novel approach for construction of a bioprosthetic heart valve”, Eur. J. Cardio-thoracic Surg.; 11: 493-497, 1997.
Schmidt, C., Shastri, V., Vacanti, J., Langer, R. “Stimulation of neurite outgrowth using an electrically conducting polymer”, PNAS; 94: 8948-8953, 1997.
Chen, H., Langer, R., Edwards, D. “A film tension theory of phagocytosis”, J. Colloid and Interfac. Sci.; 190: 118-133, 1997.
Cook, A., Pajvani, U., Hrkach, J., Cannizzaro, S., Langer, R. “Colorimetric analysis of surface reactive amino groups on poly(lactic acid-co-lysine): poly(lactic acids) blends”, Biomaterials; 18: 1417-1424, 1997.
Gupta, R., Alroy, J., Alonso, M., Langer, R., Siber, G. “Chronic local tissue reactions, long term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polmers”, Vaccine; 15: 1716-1723, 1997.
Cusick, R., Lee, H., Sano, K., Pollok, J., Utsunomiya, H, Ma, P., Langer, R., Vacanti, J. “The effect of donor and recipient age on engraftment of tissue engineered liver”, J. Pediatr. Surg.; 32: 357-360, 1997.
Shinoka, T., Shum-Tim, S., Ma, P., Tanel, R., Langer, R., Vacanti, J., Mayer, J., Jr. “Tissue-engineered heart valve leaflets. Does cell origin affect outcome?”, Circulation; 96 (suppl II): II-102-II-107, 1997.
Freed, L., Langer, R., Martin, I., Pellis, N., Vunjak-Novakovic, G. “Tissue engineering of cartilage in space”, PNAS; 94: 13885-13890, 1997.
Hanes, J., Cleland, J., Langer, R. “New advances in microsphere-based single-dose vaccine”, Adv. Drug Del. Rev.; 28: 97-120, 1997.
Uhrich, K., Larrier, D., Laurencin, C., Langer, R. “In vitro degradation characteristics of poly(anhydride imides) containing pyromellitylimidoalanine”, J. Poly. Sci.; 34: 1261-1269, 1997.
Mooney, D., Langer, R. “Engineering biomaterials for tissue engineering to 10-100 micron scale”, Bio. Engin. Handbook; Bronzino, J., ed., CRC Press, Boca Raton, FL, pp. 1609-1618, 1997.
Batycky, R., Hanes, J., Langer, R., Edwards, D. “Theoretical model of erosion and macromolecular drug release from biodegrading microspheres”, Journal of Pharmaceutical Science; 86: 1464-1477, 1997.
Mooney, D., Sano, K., Kaufmann, P., Majahod, K., Schloo, B., Vacanti, J., Langer, R. “Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges”, Journal of Biomedical Materials Research; 37: 413-420, 1997.
Johnson, M., Blankschtein, D., Langer, R. “Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism”, Journal of Pharmaceutical Science; 86: 1162-1172, 1997.
Mitragotri, S., Blankschtein, D., Langer, R. “An explanation for the variation of the efficacy of sonophoresis from drug to drug”, Journal of Pharmaceutical Science; 86: 1190-1192, 1997.
Niklason, L., Langer, R. “Advances in tissue engineering of blood vessels and other tissues”, Transplant Immun.; 5: 303-306, 1997.
Constantino, R., Liauw, S., Mitragotri, S., Klibanov, A., Langer, R., Sluzky, V. “Pharm. developments of insulin, in” Therapeutic Protein and Peptide Form. and Del. ACS Symposium Series, Shahrokh, Z., Sluzky, V., Cleland, J., Shrine, S., Randolph, T., Eds., 29-66, 1997.
Shastri, V.R., Hildgen, P., Langer, R. Najajrah, Y., Ringel, I., Domb, A. “Other polyesters, in”, Handbook of Biodegrad. Poly. A. Domb, J. Kost, D. Wiseman, eds. Harwood Academic Publishers, 119-134, 1997.
Domb, A., Elmalak, O., Shastri, V., Ta-Shma, Z., Masters, D., Ringel, I., Teomim, D., and Langer, R. “Polyanhydrides, in”, Handbook of Biodegradable Poly. A. Domb, J. Kost, D. Wiseman, eds., Harwood Academic Publishers, 135-159, 1997.
Mitragotri, S., Blankschtein, D., Langer, R. “An Explanation for the Variation of the Sonophoretic Transdermal Transport Enhancement from Drug to Drug”, Journal of Pharmaceutical Science; 86: 10, 1190-92, 1997.
Shastri, V., Tarcha, P., Padera, R., Langer, R. “Biocompatibility of photo-cured polyanhydrides for othopedic and dental applications”, Proceeding of Surfaces in Biomaterials 52-56, 1997.
Dillow, A., Dehghani, F., Foster, N., Hrkach, J., Langer, R. “Production of polymeric support materials using a supercritical fluid gas anti-solvent process”, ISSF Proceedings A: 247-250, 1997.
1996
Mitragotri, S., Blankschtein, D., Langer, R. “Transdermal drug delivery using low-frequency sonophoresis”, Pharm. Res.; 13: 411-420, 1996.
Breuer, C., Shinoka, T., Tanel, R., Zund, G., Mooney, D., Ma, P., Miura, T., Colan, S., Langer, R., Mayer, J., Vacanti, J. “Tissue engineering lamb heart valve leaflets”, Biotech and Bioeng.; 50: 562-567, 1996.
Vunjak-Novakovic, G., Freed, L., Biron, R., Langer, R. “Effects of mixing on tissue engineered cartilage”, Am. Inst. of Ch. Eng. J.; 42: 850-860, 1996.
Hrkach, J., Peracchia, M., Domb, A., Lotan, N., Langer, R. “Nanotechnology for biomaterials engineering: structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy”, Biomaterials; 18: 27-30, 1996.
Uhrich, K.; Thomas, T.; Gupta, A.; Laurencin, C. Langer, R. “In vitro degradation of poly(anhydride-imides) containing trimellitylimidoglycine”, J. Appl. Polym. Sci.; 34: 1261-69, 1996.
Attawia, M.; Uhrich, K.; Botchwey, E.; Langer, R., Laurencin, C. “In vitro bone biocompatibility of poly(anhydride-co-imides) containing pyromellitylimidoalanine”, J. Ortho. Res.; 14: 445-454, 1996.
Curley, J., Castillo, J., Hotz, J., Uezono, M., Hernandez, S., Lim, J., Tigner, J., Chasin, M., Langer, R., Berde, C. “Prolonged regional nerve blockade: injectable biodegradable bapivacaine-polyester microspheres”, Anesthesiology; 84: 1401-1410, 1996.
Shastri, V., Schmidt, C, Kim, T., Vacanti, J., Langer, R. “Polypyrrole: a potential Candidate for Stimulated Nerve Regeneration”, Matierials Research Society ProceedingsVol. 414, 113-118, 1996.
Vunjak-Novakovic, G., Freed, L., Langer, R. “Culture de chondrocytes sur des polymeres biodegradables”, Synoviale J. de Rhum. 12: 4-5, 1996.
Edwards, D., Gooch, K., Zhang, I., McKinley, G., Langer, R. “The nucleation of receptor-mediated endocytosis”, PNAS; 93: 1786-1791, 1996.
Sanchez, A., Gupta, R., Alonso, M., Siber, G., Langer, R. “A pulsed controlled release system for potential use in vaccine delivery”, J. Pharm. Sci.; 85: 547-552, 1996.
Langer, R. “Controlled release of a therapeutic protein”, Nat. Med.; 2: 742-743, 1996.
Mooney, D, Kaufman, P., . Sano, K., Schwendeman, S., McNamara, K., Schloo, B., Vacanti, J., Langer, R. “Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes”, Biotech. and Bioeng.; 50: 422-429, 1996.
Sano, K., Cusick, R., Lee, H., Pollok, J., Kaufmann, P., Uyama, S., Mooney, D., Langer, R., Vacanti, J. “Regenerative signals for hetertopic hepatocyte transplantation”, Trans. Proc. 28: 1857-1858, 1996.
Ibarra, C., Langer, R., Vacanti, J. “Tissue engineering: cartilage, bone, and muscle”, 235-245, Lanza R., Chick W., eds. The Netherlands: Kluwer Academic Publishers, 1996.
Brem, H., Langer, R. “Polymer-Based Drug Delivery to the Brain”, Sci. and Med. 3: 52-61, 1996.
Johnson, M., Mitragotri, S., Patel, A., Blankschtein, D., Langer, R. “Synergistic Effects of Chemical Enhancers and Therapeutic Ultrasound on Transdermal Drug Delivery”, J. Pharm. Sci.; 85: 7, 670-679, 1996.
Mooney, D., Mazzoni, C., Breuer, C., McNamara, K., Hern, D., Vacanti, J., Langer, R. “Stabilized polyglycolic acid fiber-based devices for tissue engineering”, Biomaterials; 17: 115-124, 1996.
Kost, J., Pliquett, U., Mitragotri, S., Yamamoto, A., Langer, R., Weaver, J. “Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport”, Pharm. Res.; 13: 4, 633-638, 1996.
Edwards, D., Schneck, F., Zhang, I., Davis, A., Chen. H., Langer, R. “Spontaneous vesicle formation at lipid bilayer membranes”, Biophys. J.; 71: 1208-1214, 1996.
Schwendeman, S., Cardamone, M., Brandon, M., Klibanov, A., Langer, R. “Stability of proteins and their delivery from biodegradable polymer microspheres”, Microspheres/ Microparticulates Charact. and Pharm. App. 1-49, H. Bernstein, S. Cohen, eds. Marcel Dekker, Inc., N.Y , 1996.
Sasisekharan, R., Venkataraman, G., Godavarti, R., Ernst, S., Cooney, C., Langer, R. “Heparinase I from Flavobacterium heparinum: The mapping and characterization of the heparin binding domain”, J. Bio. Chem.271: 3124-31, 1996.
Schwendeman, S., Costantino, H., Gupta, R., Tobio, M., Chang, A., Alonso, M., Siber, G., Langer, R. “Strategies for stabilizing tetanus toxoid toward the development of a single-dose tetanus vaccine”, Dev. in Bio. Standardization 87: 293-306, 1996.
Li, W., Perzl, M., Heyder, J., Langer, R., Brain, J., Englemeir, K.H., Niven, R., Edwards, D. “Aerodynamics and Aerosol Particle Deaggreation Phenomena in Model Oral-Pharyngeal Cavities”, J. Aerosol Sci. 27, 1269-1286, 1996.
Langer, R. “Polymeric drug delivery systems”, Idea to Product: The ProcessElsevier Publishers, N. Alexander, Wentz, A. eds., 53-67, 1996.
Venkataraman, G., Sasisekharan, V., Herr, A., Ornitz, D., Waksman, G., Cooney, C., Langer, R. Sasisekharan, R. “Preferential self-association of fibroblast growth factor is stabilized by heparin during receptor dimerization and activation”, PNAS; 93: 845-50, 1996.
Ernst, S., Venkataraman, G., Winkler, S., Godavarti, R., Langer, R., Cooney, C., Sasisekharan, R. “Expression in Escherichia coli, purification, and characterization of heparinase I from flavobacterium heparinum”, Biochem. J.; 315: 589-97, 1996.
Johnson, M., Berk, D., Blankschtein, D., Golan, D., Jain, R., Langer, R. “Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems”, Biophvs. J.; 71: 2656-2668, 1996.
Chen, H. and Langer, R. “Polymerized liposomes as oral vaccine carriers: Stability and bioavailability”, J. Cont. Rel.; 42: 263-272, 1996.
Yaszemski, M., Payne, R, . Hayes, W., Langer, R., Mikos, A. “Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone”, Biomaterials; 17: 2, 175-185, 1996.
Mooney, D., Kim, B-S, Vacanti, J., Langer, R. “Tissue engineering: Urogenital systems”, Textbook of Tissue Engineering, 587-596, Lanza, R., Chick, W., R. Langer, eds. Textbook of Tiss. Eng., Springer-Verlag, Berlin, Germany, 1996.
Pliquett, U., Zewert, T., Chen. T., Langer, R., Weaver, J. “Imaging of fluorescent molecule and small ion transport through human stratum corneum during high-voltage pulsing: Localized transport regions are involved”, J. Biophvs. Chem 58: 185-204, 1996.
Prausnitz, M., Gimm, J., Weaver, J., Guy, R., Langer, R., Cullander, C. “Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures”, J. Pharm. Sci.; 85: 1363-1370, 1996.
Edelman, E., Brown, L., Langer, R. “Quantification of insulin release from implantable polymer-based delivery systems and augmentation of therapeutic effect with simultaneous release of somatostatin”, J. Pharm. Sci.; 85: 1271 -75, 1996.
Brown, L., Edelman, E., Fischel-Ghodsian, F., Langer, R. “Characterization of glucose-mediated insulin release from implantable polymers”, J. Pharm. Sci.; 85: 1341-45, 1996.
Costantino, H., Schwendeman, S., Griebenow, K., Klibanov, A., Langer, R. “The Secondary Structure and Aggregation of Lyophilized Tetanus Toxoid”, J. Pharm. Sci.; 85: 1290-93, 1996.
Schwendeman, S., Costantino, H., Gupta, R., Langer, R. “Progress and challenges for peptide, protein and vaccine delivery from implantable polymeric systems”, Cont. Drug Del.: The Next Generation Park, K., ed., The American Chemical Society, Washington, 1996.
Kohn, J., Langer, R. “Bioresorbable and bioerodible materials”, Bio. Sci., An Introduction to Materials in Medicine Ratner, B., Hoffman, A., Schoen, F., Lemons, J., eds., 64-72, Academic Press, New York, NY, 1996.
Chen, H., Langer, R. “Lectin-bearing polymerized liposomes as potential oral vaccine carriers”, Pharm. Research; 13: 1378-1383, 1996.
Hanes, J., Langer, R. “Polymeric controlled release vaccine delivery systems”, Reproductive Immunology R. Bronson, N. Alexander, D. Anderson, D., Branch, Kutteh, W., eds., Blackwell Scientific Publications, Inc., Boston, 647-664, 1996.
Moses, M., Marikovsky, M. Harper, J., Vogt, P., Eriksson, E., Klagsbrun, M., Langer, R. “Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing”, J. Cell. Biochem.; 60: 379-386, 1996.
Prausnitz, M., Lee, C., Liu, C., Pang, J., Singh, T., Weaver, J., Langer, R. “Transdermal transport efficiency during skin electroporation and iontophoresis”, J. Contr. Rel.; 38: 205-217, 1996.
Mooney, D., Baldwin, D., Suh, N., Vacanti, H., Langer, R. “A novel approach to fabricate porous sponges of poly(D, L-lactic-co-glycolic acid) without the use of organic solvents”, Biomaterials; 17: 1417-1422, 1996.
Hrkach, J., Ou, J., Lotan, N., Langer, R. “Poly(L-lactic acid-co-amino acid) Graft Copolymers: a class of functional, biodegradable biomaterials”, Hydrogels and Biodegrad. Poly. for Bioapp. 8: 93-102, Ottenbrite, R., Huang, S., Park, K., eds. ACS Symposium Series 627; ACS: Washington, DC , 1996.
Shinoka, T., Ma, P., Shum-Tim, D., Breuer, C., Cusick, R., Zund, G., Langer, R., Vacanti, J., Mayer, J. “Tissue-engineered heart valves: autologous valve leaflet replacement study in a lamb model”, Sup. II Circulation 94: 164-168, 1996.
Kline, D.F., Hanes, J., Langer, R. “Adjuvant-active polymeric microparticles vaccine-delivery systems”, Microparticulate Systems for the Delivery of Protiens and Vaccines Cohen, S., and Bernstein, H., eds., Marcel Dekker, Inc. , New York, 349-380, 1996.
Hanes, J., Chiba, M., Langer, R. “Synthesis and characterization of degradable (anhydride-co-imide) terpolymers containing trimellitylimido-L tyrosine: novel polymers for drug delivery”, Macromolecules; 29: 5279-5287, 1996.
Cohen, S., Bano, M. Cima, L., Allcock, H., Vacanti, J., Vacanti, C., Langer, R. “Design of synthetic polymeric structures for cell transplantation and tissue engineering”, Clinic. Mat.13: 3-10, 1996.
488. Castillo J., Curley, J., Hotz, J., Uezono M., Tigner, J., Chasin, M., Langer, R., Berde C. “Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres”, Anesthesiology; 85: 1157-1166, 1996.
Godavarti, R., Cooney, C., Langer, R., Sasisekharan, R. “Heparinase I from Flavohacterium heparinum, Identification of a critical histidine residue essential for catalysis as probed by chemical modification and site directed mutagenesis”, Biochemistry; 35: 6846-6852, 1996.
Kost, J., Pliquet, U., Mitragotri, S., Yamamoto, A., Langer, R., Weaver, J. “Synergistic Effect of Ultrasound and Electroporation on Transdermal Drug Delivery”, Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 23, 1996.
Mitragotri, S., Blankschtein, D., Langer, R. “Transdermal Drug Delivery Using Low-Frequency Sonophoresis”, Pharmaceutical Research; 13: 3, 411-420, 1996.
Mitragotri, S., Blankschtein, D., Langer, R. “Sonophoresis: Enhanced Transdermal Drug Delivery by Application of Ultrasound”, Encl. Of Pharm. Tech. Swarbrick, J., Boylan, J., Eds., 14: 103-122, 1996.
Anseth, K., Shastri, V., Laurencin, C., Langer, R. “Photo-polymerization of novel degradable networks for orthopaedic applications”, ACS Polymer Materials Society Science Proceedings 74: 385-386, 1996.
Godavarti, R., Davis, M., Venkataraman, G., Conney, C., Langer, R., Sasisekharan, R. “Cloning and recombinant expression of Heparinases I, II, and III from flavobacterium heparinum”, Biochemistry and Biophysical Research Community 225: 751-758, 1996.
Schwendeman, S., Costantino, H., Gupta, R., Klibanov, A., Langer, R. “Peptide, protein and vaccine delivery from implantable polymer systems”, Controlled Drug Del.: Challenges and Strategies 229-267. K Park, ed., American Chemical Society, Washington, DC, 1996.
1995
Shefer, S., Breslau, J., Langer, R. “Computer Simulation of LDL removal in the Presence of a Bioreactor Containing Phospholipase A2”, Biotech. Prog.; 11: 133-139, 1995.
Hubbell, J., Langer, R. “Tissue engineering”, Chem. & Eng. News; 42-54, 1995.
Yaszemski, M., Payne, R., Hayes, W., Langer, R. Aufdemorte, T., Mikos, A. “The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold”, Tiss. Eng.; 1: 41-45, 1995.
Mitragotri, S., Edwards, D., Blankschtein, D., Langer, R. “A Mechanistic Study of Ultrasonically Enhanced Transdermal Drug Delivery”, J. Pharm. Sci.; 84: 697-706, 1995.
Goepferich, A., Langer, R. “Modeling monomer release from bioerodible polymers”, J. Cont. Rel.; 33: 5569, 1995.
Uhrich, K., Gupta, A., Thomas, T., Laurencin, C., Langer, R. “Synthesis and characterization of degradable poly(anhydride-co-imides)”, Macromolecules; 28: 2184-2193, 1995.
Mooney, D., Sano, K., Kaufmann, P., McNamara, K., Vacanti, J., Langer R. “Intergating Cell Transplantation and Controlled Drug Deliverly Technologies to Engineer Liver Tissue”, Materials Research Society Proceedings; Vol. 394: 83-89, 1995.
Cao, Y., Vacanti, J., Ma, P., Paige, K., Upton, J., Langer, R., Vacanti, C. “Tissue Engineering of Tendon”, Materials and Research Society Proceedings; Vol. 394: 91-97, 1995.
Edwards, D., Prauznitz, M., Langer, R., Weaver, J. “Analysis of enhanced transdermal transport by skin electroporation”, J. Cont. Rel.; 34: 211-221, 1995.
Venkataraman, G., Sasisekharan, V., Cooney, C., Langer, R., Sasiskharan, R. “Complex Flexibility of TGF-13 Super Family”, PNAS; 92: 5406-5410, 1995.
Mylonas, C., Tabata, Y., Langer, R., Zohar, Y. “Preparation and evaluation of polyanhydride microspheres containing gonadotropin-releasing hormone (GnRH), for inducing ovulation and spermiation in fish”, J. Cont. Rel.; 35: 23-34, 1995.
Cohen, S., Langer, R. “Long-term protein delivery from microencapsulated liposome systems”, Liposomes, New Sys. and New Trends in Their Appl.; R. Puisieux, P. Couvreur, J. Delattre, J-P. Devissaguet, eds., Editions de Sante, Paris, France, 275-291, 1995.
Thomson, R., Ishaug, S., Mikos, A., Langer, R. “Polymer for Biological Systems”, The Encyclopedia of Molec. Biol. and Biotech; R. Meyer, ed. VCH Publishers, New York, NY, 717-724, 1995.
Ishaug, S.L., Thomson, R.C., Mikos, A., Langer, R. “Biomaterials for Organ Regeneration”, The Encyc. of Molec. Biol. and Biotech; R.A. Meyer, ed. VCH Publishers, NY, NY, pp. 86-93, 1995.
Hanes, J., Chiba, M., Langer, R. “Polymer Microspheres for Vaccine Delivery”; M. Powell, M. Newman, eds. 16: 389-412, Plenum, New York, 1995.
Cao, Y., Vacanti, J., Ma, X., Paige, K., Upton, J., Chowanski, Z., Schloo, B., Langer, R., Vacanti, C. “Generation of neo-tendon using synthetic polymers seeded with tenocytes”, Transplant. Proc.; 26: 3390-3391, 1955.
Sakata, J., Vacanti, C., Schloo, B., Healy, G., Langer, R., Vacanti, J. “Tracheal composites tissue engineered from chondrocytes, tracheal epithelial cells, and synthetic degradable scaffolding”, Transplant. Proc.; 26: 3309-3310, 1995.
Langer, R. “Biomaterials: New Polymers and Novel Applications”, MRS Bulletin; 20: 18-22, 1995.
Zewert, T., Pliquett, U., Langer, R., Weaver, J. “Transdermal Transport of DNA Antisense Oligonucleotides by Electroporation”, Biochem. and Biophys. Res. Comm.; 212: 286-292, 1995.
Hrkach, J., Ou, J., Lotan, N., Langer, R. “Synthesis of Poly(L-lactic acid-co -L-Lysine) Graft Copolymers”, Macromolecules; 28: 4736-4739, 1995.
Mitragotri, S., Blankschtein, D., Langer, R. “Ultrasound-mediated transdermal protein delivery”, Science; 269: 850-853, 1995.
Langer, R., Vacanti, J. “Artificial Organs”, Sci. Amer.; 273: 130-133, 1995.
Johnson, M., Blankschtein, D., Langer R. “Permeation of steroids through human skin”, J. Pharm. Sci.; 84: 1144-1146, 1995.
Langer, R., Vunjak, G., Freed, L., Atala, A., Vacanti, C., Vacanti, J. “Tissue Engineering: Biomedical Applications”, Tissue Engin.; 1: 151-162, 1995.
Mooney, D., Breuer, C., McNamara, K, Vacanti, J., Langer R. “Fabricating tubular devices from polymers of lactic and glycolic acid for tissue engineering”, Tissue Engin.; 1: 107-118, 1995.
Cohen, S., Langer, R. “Novel liposome-based formulations for prolonged delivery of proteins and vaccines”, J. Liposome Res.; 5: 813-828, 1995.
Payne, L., Jenkins, S., Andrianov, A., Langer, R., Roberts, B. “Xenobiotic Polymers as Vaccine Vehicles”, Adv. in Exper. Med. and Biol.; 1475-1480, 1995.
Okada, J., Cohen, S., Langer, R. “In vitro evaluation of polymerized liposomes as an oral drug delivery system”, Pharm. Res.; 1/7/2002 12:04, 1995.
Laurencin, C., Sobrasua, E., Ibim, M., Langer, R. “Biomedical Applications of Synthetic Biodegradable Polymers”, CRC Press; J.Hollinger, ed., New York, pp. 59-102, 1995.
Shefer, S., Rosenberger, V., Vahanian, G., Wong, W., Langer, R. “Implantable hollow fiber bioreactor as a potential treatment for hypercholesterolemia: characterization of the catalytic unit”, Biotech & Bioeng; 48: 36-41, 1995.
Goepferich, A., Langer, R. “Modeling of Polymer Erosion in Three Dimensions”, AIChE J.; 41: 289-299, 1995.
Prausnitz, M., Corbett, J., Gimm, J., Golan, D., Langer, R., Weaver, J. “Millisecond measurement of transport during and after an electroporation pulse”, Biophys. J.; 68: 1864-1870, 1995.
Wake, M., Mikos, A., Sarakinos, G., Vacanti, J., Langer, R. “Dynamics of fibrovascular tissue ingrowth in hydrogel foams”, Cell Transpl.; 4: 275-2791995, 1995.
Langer, R. “1994 Whitaker Lecture: Polymers for drug delivery and tissue engineering”, Annals of Biomed. Eng.; 23: 101-111, 1995.
Ma, P., Schoo, B, Mooney, D., Langer, R. “The development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage”, J. Biomed. Mat. Res.; 29: 1587-1595, 1995.
Schwendeman, S., Costantino, H., Gupta, R., Siber, G., Klibanov, A., Langer, R. “Stabilization of tetanus and diptheria toxoids against moisture-induced aggregation”, PNAS; 92: 11234- 11238, 1995.
Prausnitz, M., Edelman, E., Gimm, J., Langer, R., Weaver, J. “Transdermal delivery of heparin by skin electroporation”, Bio/Tech.; 13: 1205-1209, 1995.
Ma, P., Langer, R. “Degradation, structure and properties of fibrous nonwoven poly(glycolic acid) scaffolds for tissue engineering”, Poly. in Med. Pham.; Mikos, A., Leong, K., Radomsky, M., Tamada, J., Yaszemski, M., eds., 394: 99-104, 1995.
Shinoka, T., Breuer, C., Tanel, R., Zund, G., Miura, T., Ma, P., Langer, R., Vacanti, J., Mayer, J. “Tissue engineering heart valves: valve leaflet replacement study in a lamb model”, Annals of Thoracic Surg.; 60: S513-516, 1995.
Costantino, H., Langer, R., Klibanov, A. “Aggregation of a lyophilized pharm. protein, recombinant human albumin: effects of moisture and stabilization by excipients”, Bio/Techn.; 13: 493-496, 1995.
Weaver, J., Langer, R., Potts, R. ” Tissue electroporation for localized drug delivery”, Enviro. Elec. and Magnet. Fields; Blank, M., ed. American Chemical Society, 301-316, 1995.
Sasisekharan, R., Leckband, D., Godavarti, R., Venkataraman, G., Cooney, C., Langer, R. “Heparinase I from flavobacterium heparinum: The role of cysteine residue in catalysis as probed by chemical modification and site-directed mutagenesis”, Biochemistry; 34: 14441-14448, 1995.
Langer, R. “Biomaterials and biomedical engineering”, Chem. Eng. Sci.; 50: 4109-4121, 1995.
Pliquett, W., Langer, R., Weaver, J. “Changes in the passive electrical properties of human stratum corneum due to electroporation”, Biochim. Biophys. Acta; 1239: 111-121, 1995.
Cusick, R., Sano, K., Lee, H., Pollok, J., Mooney, D., Langer, R., Vacanti, J. “Heterotopic fetal rat hepatocyte transplantation on biodegradable polymers”, Am. Coll. of Surgeons Surg. Forum; 46: 658-661, 1995.
Prausnitz, M., Bose, V., Langer, R., Weaver, J. “Electroporation”, Percutaneous Penetration Enhancers; H. Maibach, E. Smith, eds., CRC Press, Boca Raton, FL, 393-405, 1995.
Costantino, H., Griebenow, K., Mishra, P., Langer, R., Klibanov, A. “Fourier-transform infrared (FTIR) spectroscopic investigation of protein stability in the lyophilized form”, Biochim. Biophys. Acta; 1253:69-74, 1995.
Ernst, S., Langer, R., Cooney, C., Sasisekharan, R. “Enzymatic degradation of glycosaminoglycans”, CRC Critical Rev. Biochem. Mol. Biol.; 30: 387-444, 1995.
Mooney, D., Langer, R., Ingber, D. “Cytoskeletal filament assembly and the control of cell shape and function by extracellular matrix”, J. Cell Sci.; 108: 2311-2320, 1995.
Barrera, D., Zylstra, E., Lansbury, P., Langer, R. “Copolymerization and degradation of poly(lactic Langer, R., Polymers for Drug Delivery and Tissue Engineering”, Macromolecules; 28: 425-432, 1995.
Hrkach, J., Ou, J., Lotan, N., Langer, R. “Poly(L-Lactic acid-co-aspartic acid): Interactive Polymers for Tissue Engineering”, Mat. Res. Soc. Symp. Proc.; 394: 77-82, 1995.
Goepferich, A., Karydas, D., Langer, R. “Predicting drug release from cylindric polyanhydride matrix discs”, European J. of Pharm. and Biopharm.; 41(2): 81-87, 1995.
Mitragotri, S., Edwards, D., Blankschtein, D., Langer, R. “Quantitative Prediction of Ultrasonically Enhanced Transdermal Drug Delivery”, Proceed. Intern. Symp. Control. Rel. Bioact. Mater.; 22, 1995.
Attawia, M., Uhrich, K., Botchwey, B., Fan, M., Laurencin, C., Langer, R. “Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications”, J. Biomed. Mat. Res.; 29, 1233-1240, 1995.
1994
Cleland, J., Langer, R. “Formulation and delivery of proteins and peptides: Design and development strategies”, ACS Symps. Ser; 567: l-19, 1994.
Sasisekharan, R., Moses, M., Nugent, A., Cooney, C., Langer, R. “Heparinase inhibits neovascularization”, PNAS; 91: 1524-1528, 1994.
Wu, M., Tamada, J., Brem, H., Langer, R. “In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy”, J. Biomed. Mat. Res.; 28: 387-395, 1994.
Gref, R., Minamitake, Y., Peracchia, M., Trubetshoy, V. Torchillin, V., Langer, R. “Biodegradable long- circulating polymeric nanospheres”, Science; 263: 1600-1603, 1994.
Wong, J., Langer, R., Ingber, D. “Novel applications for electrically conducting polymers: Control of cell shape on polypyrrole thin films”, Proc. Nat. Acad. Sci.; 91: 3201-3204, 1994.
Shieh, L., Tamada, J., Tabata, Y., Domb, A., Langer, R. “Drug Release from a New Family of Biodegradable Polyanhydrides”, J. Cont. Rel.; 29: 73-82, 1994.
Freed, L., Vunjak-Novakovic, G., Marquis, J., Langer, R. “Kinetics of Chondrocyte Growth in Cell- Polymer Implants”, Biotech. Bioengin.; 43: 597-604, 1994.
Alonso, M., Gupta, R., Min, C., Siber, G., Langer, R. “Biodegradable Microspheres as Controlled Release Tetanus Toxoid Delivery Systems”, Vaccine; 12: 299-306, 1994.
Freed, L., Marquis, J., Emmanual, J., Vunjak-Novakovic, G., Marquis, J., Langer, R. “Composition of Cell-Polymer Cartilage Implants”, Biotech. Bioeng.; 43: 605-614, 1994.
Mikos, A., Freed, L., Langer, R. “Wetting of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams for tissue culture”, Biomaterials; 15: 55-58, 1994.
Peppas, N., Langer, R. “New Challenges in Biomaterials”, Science; 263, 1715-1720, 1994.
Cohen, S., Langer, R. “Pulsatile Liposomes”, J. Liposome Res.; 4: 349-360, 1994.
Mikos, A., Thorsen, A., Czerwonka, L., Bao, Y., Winslow, N., Vacanti, J., Langer, R. “Preparation and Characterization of Poly(L-Lactic Acid) Foams for Cell Transplantation”, Polymer; 35: 1068-1077, 1994.
Prausnitz, M., Milano, C., Gimm, J., Langer, R., Weaver, J. “Quantitative Study of Molecular Transport Due to Electroporation: Uptake of Bovine Serum Albumin by Erythrocyte Ghosts”, Biophys. J.; 66: 1522-1530, 1994.
Tabata, Y., Langer, R”Polyanhydride Granules Provide Near-Constant Release of Water-Soluble Drugs”, J. Pharm. Sci.; 83: 5-11, 1994.
Freed, L., Grande, D., Emmanual, J., Kwan, M., Marquis, J., Lingbin, Z., Dunkelman, N., Langer, R. “Joint Resurfacing Using Allograft Chondrocytes and Synthetic Biodegradable Polymer Scaffolds”, J. Biomed. Mat. Res.; 28: 891-899, 1994.
Freed, L., Vunjak-Novakovic, G., Biron, R., Eagles, D., Lesnoy, D., Barlow, S., Langer, R. “Biodegradable Polymer Scaffolds for Tissue Engineering”, Bio/Tech.; 12: 689-693, 1994.
Liu, L., Kost, J., Ferreira, J., Langer, R. “Enhanced Protein Blotting from PhastGel Media to Membranes by Irradiation of Low Intensity Ultrasound”, Anal. Biochem.; 216: 27-32, 1994.
Venkataraman, G., Sasisekharan, V., Cooney, C., Langer, R., Sasisekharan, R. “A Stereochemical approach to pyranose ring flexibility. Its implications on the conformation of dermatan sulfate”, PNAS; 91: 6171-6175, 1994.
Kost, J., Liu, L., Gabelnick, H., Langer, R. “Ultrasound as a Potential Trigger to Terminate the Activity of Contraceptive Delivery Implants”, J. Cont. Rel.; 30: 77-81, 1994.
Johnson, L., Aiken, J., Mooney, D., Schloo, B., Cima, L., Langer, R., Vacanti, J. “The Mesentery as a Laminated Vascular Bed for Hepatocyte Transplantation”, Cell Transpl.; 3: 273-281, 1994.
Goepferich, A., Gref, R., Minamitake, Y., Shieh, L., Alonso, M., Tabata, Y., Langer, R. “Drug Delivery from Bioerodible Polymers: Systemic and Intravenous Administration”, Formulation and Del. of Proteins and Peptides; ACS Press, Washington, D.C., ACS Symp. Series 567, J. Cleland, R. Langer, eds., 242-277, 1994.
Cohen, S. Langer, R. “Inter and Intracellular Targeting of Drugs”, Homing Mech. and Cell. Targeting; 217-231, 1994.
Mooney, D., Mazzoni, C., Organ, G., Puelacher, W., Vacanti, J., Langer, R. “Stabilizing fiber based cell delivery devices by physically bonding adjacent fibers”, Mat. Res. Soc. Proc.: Biomat. for Drug and Cell Del.; 331: 47-52, 1994.
Ferreira, J., Sasisekharan, R., Louie, O., Langer, R. “A study on the functional sub-units of phospholipase A2 by enzyme immobilization”, Biochem. J.; 303: 527-530, 1994.
Puelacher, W., Mooney, D., Langer, R., Vacanti, J., Vacanti, C. “Design of nasoseptal cartilage replacement synthesized from biodegradable polymers and chondrocytes”, Biomaterials; 15: 774-778, 1994.
Ferreira, J., Sasisekharan, R., Louie, O., Langer, R. “Carbodiimide Modification Enhances Activity of Pig Pancreatic Phospholipase A2”, Eur. J. of Biochem.; 223: 611-616, 1994.
Edwards, D., Langer, R. “A linear theory of transdermal transport phenomena”, J. Pharm. Sci.; 83: 1315-1334, 1994.
Sakata, J., Vacanti, C., Schloo, B., Healy, G., Langer, R., Vacanti, J. “Tracheal composite tissue engineered from chondrocytes, tracheal epithelial cells and synthetic degradable scaffolding”, Transplant Proc.; 26: 3309-3310, 1994.
Costantino, H., Langer, R., Klibanov, A. “Solid-Phase Aggregation of Proteins under Pharmly Relevant Conditions”, J. Pharm. Sci.; 83: 1662-1666, 1994.
Goepferich, A., Alonso, M., Langer, R. “Development and characterization of microencapsulated microspheres”, Pharm Res.; 11: 1568- 1574, 1994.
Cohen, S., Langer, R. “Novel Approaches to controlled release antigen delivery”, Internat. J. of Techn. Assessm. in Health Care; A. Robbins, P. Freeman, eds. Cambridge University Press, 10:1, 121-130, 1994.
Rosenthal, R., Moses, M., Shintani, Y., Megyesi, J., Langer, R., Folkman, J. “Purification and Characterization of a Mouse Sarcoma 180-Derived Collagenase Inhibitor which also Inhibits Endothelial Cell DNA Synthesis”, J. Cell Biochem.; 56: 97-105, 1994.
Park, T., Alonso, M., Langer, R. “Controlled release of proteins from poly (L-lactic acid) coated poly (isobutylcyanoacrylate) microcapsules”, J. Appl. Poly. Sci.; 52: 1797-1807, 1994.
Andrianov, A., Payne, L., Visscher, K., Allcock, H., Langer, R. “Hydrolytic degradation of tonically cross-linked polyphosphazene microspheres”, J. Appl. Poly. Sci.; 53: 1573-78, 1994.
Vacanti, C., Vacanti, J., Langer, R. “Tissue Engineering Using Synthetic Biodegradable Polymers”, Poly. of Bio. and Biomed. Signif.; ACS Symposium Series 540, Chicago, IL., 16-34, 1994.
Costantino, H., Langer, R., Klibanov, A. “Moisture-Induced Aggregation of Lyophilized Insulin”, Pharm. Res.; 11: 21-29, 1994.
Prausnitz, M., Pliquett, U., Langer, R., Weaver, J. “Rapid temporal control of transdermal drug delivery by electroporation”, Pharm. Res.; 11: 1834-1837, 1994.
Langer, R. “Polymer systems for controlled release of macromolecules, immobilized enzyme medical bioreactors, and tissue engineering”, Adv. in Chem. Eng.; 19: 1-50, 1994.
Mooney, D., Organ, G., Vacanti, J., Langer, R. “Design and fabrication of biodegradable polymer devices to engineer tubular tissues”, Cell Transplant.; 3: 203-210, 1994.
Brem, H., Walter, K., Tamargo, R. Olivi, A., Langer, R. “Drug Delivery to the brain”, Poly. Site Spec. Pharm.; 117-139, John Wiley & Sons, New York, 1994.
Takeda, T., Kim, T., Lee, S., Langer, R., Vacanti, J. “Hepatocyte transplantation in biodegradable polymer scaffolds using the Dalmation dog model of hyperuricosuria”, Transplant. Proc.; 27: 635-636, 1994.
Shieh, L., Tamada, J., Chen, I., Pang, J., Domb, A., Langer, R. “Erosion of a New Family of Biodegradable Polyanhydrides”, J. Biomed. Mat. Res.; 28: 1465-1475, 1994.
Mooney, D., Kaufmann, P., Sano, K., McNamara, K., Vacanti, J., Langer, R. “Transplantation of hepatocytes using porous biodegradable sponges”, Transplant. Proc.; 26: 3425-26, 1994.
Puelacher, W., Mooney, D., Langer, R., Vacanti, J., Vacanti, C. “Tissue engineered growth of cartilage: The effect of varying the concentration of chondrocytes seeded onto synthetic materials”, Int. J. Oral Maxillofacial Surg.; 23: 49-53, 1994.
Mooney, D., Hansen, L., Langer, R., Vacanti, J., Ingber, D. “Extracellular matrix controls tubulin monomer levels by regulating protein turnover”, Mol. Biol. Cell.; 5: 1281-1288, 1994.
Mooney, D., Park. S., Kaufmann, P., Sano, K., McNamara, K, . Vacanti, J., Langer, R. “Biodegradable sponges for hepatocyte transplantation”, J. Biomed. Mat. Res.; 29: 959-966, 1994.
Mooney, D., Kaufmann, P., Sano, K., McNamara, K., Vacanti, J., Langer, R. “Transplantation of Hepatocytes Using Porous, Biodegradable Sponges”, Transplant. Proc.; 26: 6, 3425-3426, 1994.
1993
Freed, L., Vunjak-Novakovic, G., Bernstein, H., Cooney, C., Langer, R. “The Kinetics of Immobilized Heparinase in Human Blood”, Annals of Biomed. Eng.; 21: 67-76, 1993.
Mikos, A., Bao, Y., Ingber, D., Vacanti, J. Langer, R. “Preparation of poly(glycolic acid) bonded fiber structures for cell transplantation”, J. Biomed. Med. Res.; 27: 183-189, 1993.
Tamada, J., Langer, R. “Erosion Kinetics of Hydrolytically Degradable Polymers”, PNAS; 90: 552-556, 1993.
Gross, A., Langer, R., Mathiowitz, E., Mayberg, M. “Sustained Release of Acetylcholine in Rat Hippocampus Using a Polyanhydride Drug Delivery System”, Poly. for Adv. Tech.; 3: 331-335, 1993.
Freed, L., Marquis, J., Nohria, A., Mikos, A., Emmanual, J., Langer, R. “Neocartilage formation in vitro and in vivo using Cells Cultured on Synthetic Biodegradable Polymers”, J. Biomed. Mat. Res.; 27: 11-23, 1993.
Shefer, S., Ferreira, J., Mullon, C., Langer, R. “Extracorporeal Enzymatic Removal of Low density Lipoproteins in Rabitts: Efficacy and Safety”, The Inter. J. Artif. Organs; 16: 115-125, 1993.
Wald, H.L., Sarakinos, G., Mikos, A., Vacanti, J., Langer, R. “Cell seeding in porous transplantation devices”, Biomaterials; 14: 270-278, 1993.
Tabata, Y., Langer, R. “Polyanhydride Microspheres that Display Near-constant Release of Water soluble drugs”, Pharm. Res.; 10: 391-399, 1993.
Tabata, Y., Gutta, S., Langer, R. “Controlled Delivery Systems for Proteins Using polyanhydride Microspheres”, Pharm. Res.; 10: 487-496, 1993.
Brem, H., Walter, K., Langer, R. “Polymers as Controlled Drug Delivery Devices for the treatment of Malignant Brain Tumors”, Eur. J. Pharm. and Biopharm.; 39: 2-7, 1993.
Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. “Laminated Three-dimensional Biodegradable Foams for Use in Tissue Engineering”, Biomaterials; 14: 323-330, 1993.
Sasisekharan, R., Bulmer, M., Moremen, K.W., Cooney, C., Langer, R. “Cloning and expression of heparinase I gene from flavobacterium heparinum”, PNAS; 90: 3660-3664, 1993.
Gilbert, J., Takeda, T., Stein, J., Langer, R., Vacanti, J. “Cell Transplantation of Genetically Altered Cells on Biodegradable Polymer Scaffolds in Syngeneic Rats”, Transplantation; Vol. 56, No. 2: 423-427, 1993.
Labeque, R., Mullon, C., Ferreira, J., Lees, R., Langer, R. “Enzymatic modification of plasma low density dipoproteins: a potential treatment for hypercholesterolemia”, PNAS; 90: 3476-3480, 1993.
Laurencin, C., Gerhart, T., Witschger, P., Satcher, R., Domb, A., Hanff, P., Edsberg, L., Hayes, W., Langer, R. “Bioerodible poly(anhydrides) for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system”, J. Orthoped. Res.; 11: 256-262, 1993.
Ron, E., Turek, T., Mathiowitz, E., Chasin, M., Hageman, M., Langer, R. “Release of Polypeptides from Polyanhydrides”, PNAS; 90: 4176-4180, 1993.
Fontaine, M., Hansen L., Thompson, S., Uyama S., Ingber, D., Mulligan, R., Langer, R., Vacanti, J. “Transplantation of genetically altered hepatocytes using cell-polymer constructs leads to sustained human growth hormone secretion in vivo”, Transplant. Proc.; 25: 1002-1004, 1993.
Langer, R., Vacanti, J. “Tissue Engineering“, Science; 260: 920-926, 1993.
Abstract / Full-text (pdf)
Bhagat, H., Langer, R. “Implants and Implantation Technology”, Encyclopedia of Pharm. Tech.; 8: 53-82, 1993.
Gupta, R., Siber, G., Alonso, M., Langer, R. “Development of a Single-dose tetanus toxoid based on controlled release from biodegradable and biocompatible polyester microspheres”; 93: 391-396, 1993.
Cima, L., Langer, R. “Tissue Engineering”, Chem Eng. Progress; 6: 54-46, 1993.
Prausnitz, M., Lau, B., Milano, C., Conner, S., Langer, R., Weaver, J. “A quantitative study of electroporation showing a plateau in net molecular transport”, Biophys. J.; 65:414-422, 1993.
Edelman, E., Langer, R. “Optimization of release from magnetically controlled polymeric drug release devices”, Biomaterials; 14: 8, 621-626, 1993.
Prausnitz, M., Bose, V., Langer, R., Weaver, J. “Transtissue Molecular Transport Due to Electroporation of Skin”, Electricity and Magnetism in Bio. and Med.; M. Blank, ed. San Francisco Press, San Francisco, CA, 122-124, 1993.
Lau, B., Milano, C., Prausnitz, M., Langer, R., Weaver, J. “Quantitative Determination of Molecular Transport Across Erythrocyte Ghost Membranes by Electroporation”, Electricity and Magnetism in Bio. and Med.; M. Blank, ed. San Francisco Press, San Francisco, CA, 141-143, 1993.
Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. “Preperation of Poly(glycolic acid) Bonded Fiber Structures for Cell Attachment and Transplantation”, J. Biomed. Mater. Res.; Vol. 27, No. 2: 183-189, 1993.
Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. “Laminated Three Dimensional Biodegradable Foams for use in Tissue Engineering”, Biomaterials; Vol. 14, No. 5: 323-330, 1993.
Alonso, M., Cohen, S., Park, T., Gupta, R., Siber, G., Langer R. “Determinants of release rate of tetanus vaccine from polyester microspheres”, Pharm Res.; 10: 945-953, 1993.
Goepferich, A., Langer, R. “The influence of microstructure and monomer properties on the erosion mechanism of a class of polyanhydrides”, J. Poly. Sci.; 31: 2445-2458, 1993.
Goepferich, A., Langer, R. “Modeling of Polymer Erosion”, Macromolecules; 22: 4105-4112, 1993.
Mikos, A., Sarakinos, G., Lyman, M., Ingber D., Vacanti, J., Langer, R. “Prevascularization of biodegradable polymer scaffolds for hepatocyte transplantation”, Biotech. & Bioeng.; 42: 716-723, 1993.
Ferreira, J., Sasisikharan, R., Louie, O., Langer, R. “Influence of chemistry in immobilization of cobra venom phospholipase A2 – Implications as to mechanism”, Biochemistry; 32: 8098-8102, 1993.
Masters, D., Berde, C., Dutta, S., Turek, T., Langer, R. “Sustained local anesthetic release from bioerodible polymer matrices: A potential method for prolonged regional anesthesia”, Pharm. Res.; 10: 1527-1532, 1993.
Masters, D., Berde, C., Dutta, S., Griggs, C., Hu, D., Kupsky, W., Langer, R. “Prolonged Regional Nerve Blockage by Controlled Release of Local Anesthetic from a Biodegradable Polymer Matrix”, Anesthesiology; 79: 340-346, 1993.
Andrianov, A., Cohen, S., Visscher, K., Payne L., Allcock, H., Langer, R. “Controlled Release Using Ionotropic Polyposphazene Hydrogels”, J. Contr. Rel.; 27: 69-77, 1993.
Langer, R. “Polymer Controlled Drug Delivery Systems”, Accts. of Chem. Res.; 26: 537-542, 1993.
Shefer, S., Payne, R., Langer, R. “Design of a biomedical reactor for plasma Low Density Lipoprotein removal”, Biotech. and Bioeng.; 42: 1252-1262, 1993.
Barrera, D., Zylstra, E., Lansbury, P., Langer, R. “Synthesis and RGD Peptide Modification of a New Biodegradable Copolymer System: Poly(Lactic Acid-co-Lysine)”, J. of Amer. Chem. Soc.; 115: 11010-11011, 1993.
Prausnitz, M., Langer, Weaver, J. “Electroporation of mammalian skin: A new mechanism to enhance transdermal drug delivery”, PNAS; 90: 10504-10508, 1993.
Prausnitz, M., Seddick, D., Kon, A., Bose, V., Frankenburg, S., Klaus, S., Langer, R., Weaver, J. “Methods for in vivo tissue electroporation using surface electrodes”, Drug Del.; 1: 125-131, 1993.
Cohen, S., Bano, M., Cima, L., Allcock, H., Vacanti, J., Vacanti, C., Langer, R. “Design of synthetic polymeric structures for cell transplantation and tissue engineering”, Clinical Mat.; 0.881944444, 1993.
Gilbert, J., Takeda, T., Stein, J., Langer, R., Vacanti, J. “Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats”, Transplantation; 56: 423-427, 1993.
Kost, J., Langer, R. “Ultrasound-mediated transdermal drug delivery”, Topical Drug Bioavailiability Bioequivalence. Penetration, ; Plenium Press, NY, V. Shah, H. Maibach, eds., 91-104, 1993.
Freed, L., Vunjak-Novakovic, G., Langer, R. “Cultivation of cell-polymer cartilage implants in bioreactors”, J. Cell. Biochem.; 51: 257-64, 1993.
Freed, L., Vunjak-Novakovic, G., Drinker, P., Langer, R. “A Bioreactor based on Suspended Particles of Immobilized Enzyme”, Annals of Biomed. Eng.; 21: 57-65, 1993.
Sheppard, N., Langer, R. “The Use of Ultrasound Attenuation to Characterize Release of Proteins from Polymer Matrix Devices”, J. Cont. Rel.; 22: 245-242, 1992.
Cohen, S., Allcock, H., Langer, R. “Cell and Enzyme Ionotropic Synthetic Hydrogels”, Recent Adv. in Pharm. and Indust. Biotech.; 3648, 1992.
Wintermantel, E., Cima, L., Schloo, B., Langer, R. “Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices”, Angiogenesis: Key Principles- Science Technology, Medicine; 331-334, 1992.
1992
Park, T., Cohen, S., Langer, R. “Poly(L-lactic acid)/Pluronic Blends: Characterization of Phase Separation Behavior, degradation, Morphology and as Protein Releasing Matrices”, Macromolecules; 25: 116-122, 1992.
During, M., Freese, A., Deutch, A., Kibat, P., Sabel, B., Langer, R., Roth, R. “Biochemical and Behavioral Recovery in a Rodent Model of Parkinson’s Disease following Stereotactic Implantation of dopamine-Containing Liposomes”, Exper. Neurology; 115: 193-199, 1992.
Mathiowitz, E., Bernstein, H., Giannos, S., Dor, P., Turek, T., Langer, R. “Polyanhydride Microspheres. IV. Morphology and characterization of systems made by spray drying”, J. Applied Polym. Sci.; 45: 125-134, 1992.
Alonso, M., Langer, R. “Biodegradable controlled release microspheres for macromolecules and proteins”, Profiles on Biotech.; T.G. Villa, J. Abalde, Eds, in Servicio de Publicacions, Universidad de Santiango, 555-564, 1992.
Cady, S., Langer, R. “Overview of protein formulations for animal health applications”, J. Agric. and Food Chem.; 40: 332-336, 1992.
Park, T., Cohen, S., Langer, R. “Controlled protein release from polyethyleneimine coated poly(lactic acid)/pluronic blend matrices”, Pharm. Res.; 9: 37-39, 1992.
Mooney, D., Hansen, L., Vacanti, J., Langer, R., Farmer, S., Ingber, D. “Different extracellular matrix molecules share a common mechanism for control of hepatocyte growth and differentiation”, J. Cell Physiol.; 3: 315-353, 1992.
Langer, R., Peppas N. “New drug delivery systems”, Bioeng. Sci. News; 16: 3-7, 1992.
Liu, L., Kost, J., D’Emanuele, A., Langer, R. “Experimental approach to elucidate the mechanism of ultrasound-enhanced polymer erosion and release of incorporated substances”, Macromolecules; 25: 123-128, 1992.
Kost, J., Langer, R. “Responsive polymer systems for controlled delivery of therapeutics”, Trends in Biotech.; 10: 127-131, 1992.
Mooney, D.J., Johnson, L., Cima, L., Hansen, L., Ingber, D., Langer, R., Vacanti, J. “Principles of tissue engineering and reconstruction using polymer-cell constructs”, Tissue-Inducing Biomat; 252: 345-352, 1992.
Mooney, D., Langer, R, Hansen, L., Vacanti, J., Ingher, D. “Induction of hepatocyte differentiation by the extracellular matrix and an RGD-containing synthetic peptide”, Tissue-Inducing Biomat.; 252: 199-204, 1992.
Tamada, J., Langer, R. “The development of polyanhydrides for drug delivery applications”, J. Biomat. Sci. Poly. Ed.; 3: 315-353, 1992.
Sheppard, N., Madrid, M., Langer, R. “Polymer matrix controlled release systems: influence of polymer carrier and temperature on water uptake and protein release”, J. Appl. Polym. Sci.; 46: 19-26, 1992.
Simons, M., Edelman, E., DeKeyser, J, Langer, R., Rosenberg, R. “Antisense c-myb oligonucleotides Inhibit arterial smooth muscle proliferation in vivo”, Nature; 359: 67-70, 1992.
Soltys, P., Mullon, C., Langer, R. “Oral treatment for jaundice using immobilized bilirubin oxidase”, Artificial Organs; 16: 331-335, 1992.
Moses, M., Sudhalter, J., Langer, R. “Isolation and characterization of an inhibitor of neovascularization for the conditioned media of scapular chondrocytes”, J. Cell Biol.; 119: 475-482, 1992.
Edelman, E., Fiorino, A., Grodzinsky, A., Langer, R. “Mechanical deformation of polymer matrix controlled release devices modulates drug release”, J. Biomed. Mat. Res.; 26: 1619, 1992.
Sluzky, V., Klibanov, A., Langer, R. “Mechanism of insulin Aggregation and Stabilization”, Agitated Aqueous Solutions, Biotech., and Bioeng.; 40: 895-903, 1992.
Shefer, S., Shefer, A., Kost, J., Langer, R. “Structural characterization of starch networks in the solid state by cross-polarization magic-angle-spinning 13C-NMR spectroscopy and wide angle x-ray diffraction”, Macromolecules; 25: 6756-6760, 1992.
Mooney, D., Hansen, L., Vacanti, J., Langer, R., Farmer, S., Ingber., D. “Switching from differentiation to growth in hepatocytes: Control by extracellular matrix”, J. Cell Physiol.151: 497-505, 1992.
Mathiowitz, E., Langer, R. “Polyanhydride Microspheres as Drug Delivery Systems”, Microcapsules in Med. and Pharm.; pp. 100-123, 1992.
D’Emanuele, A., Kost, J., Hill, J., Langer, R. “An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices”, Macromolecules; 25: 511-515, 1992.
Sheppard, N., Langer, R. “The Use of Ultrasound Attenuation to Characterize Release of Proteins from Polymer Matrix Devices”, J. Cont. Rel.; 22: 245-242, 1992.
Cohen, S., Allcock, H., Langer, R. “Cell and Enzyme Ionotropic Synthetic Hydrogels”, Recent Adv. in Pharm. and Indust. Biotech.; 3648, 1992.
Wintermantel, E., Cima, L., Schloo, B., Langer, R. “Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices”, Angiogenesis: Key Principles- Science Technology, Medicine; 331-334, 1992.
1991
Langer, R. “Pharmacology”, 1991 McGraw-Hill Yearbook of Sci. and Tech.; pp. 299-301, 1991.
Kost, J., Langer, R. “Responsive polymeric delivery systems”, Adv. Drug Del. Rev.; 6: 19-50, 1991.
Davies, M., Khan, M., Domb, A., Langer, R., Watts, J., Paul, A. “The analysis of the surface chemical structure of biomedical aliphatic polyanhydrides using XPS and ToF-SIMS”, J. Applied Poly. Sci.; 42: 1597-1605, 1991.
Langer, R. “Polymeric delivery systems”, Targeting of Drugs: 2 Optimization Strategies; 165-174, 1991.
Ron, E., Mathiowitz, E., Mathiowitz, G., Domb, A., Langer, R. “NMR Characterization of erodible copolymers”, Macromolecules; 24: 2278-2282, 1991.
Leckband, D., Langer, R. “An approach for the stable immobilization of proteins”, Biotech. Bioeng.; 37: 227- 237, 1991.
Cima, L., Ingber, D., Vacanti, J., Langer, R. “Hepatocyte culture on biodegradable polymeric substrates”, Biotech. Bioeng.; 38: 145-158, 1991.
Moses, M., Langer, R. “Biocompatible controlled release polymers for delivery systems of polypeptides and growth factors”, J. Cell. Biochem; 45: 340-345, 1991.
Staubli, A., Mathiowitz, E., and Langer, R. “Characterization of hydrolytically degradable amino acid containing poly(anhydride-co-imides)”, Macromolecules; 24: 2283-2290, 1991.
Staubli, A., Mathiowitz, E., Langer, R. “Sequence distribution and its effect on glass transition temperature of poly(anhydride-co-amides) containing asymmetric monomers”, Macromolecules; 24: 2291-2298, 1991.
Cima, L., Vacanti, J., Vacanti, C., Ingber, D., Mooney, D., Langer, R. “Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrate”, J. Biomech. Eng.; 113: 143-151, 1991.
Cohen, S., Bano, M., Chow, M., Langer, R. “Lipid-alginate interactions render changes in phospholipid bilayer Permeability”, Biochim. Biophys. Acta.; 1063: 95-102, 1991.
Bano, M., Cohen, S., Visscher, K., Allcock, H., Langer, R. “A Novel Synthetic Method for Hybridoma Cell Encapsulation”, Bio/Tech.; 9: 468-471, 1991.
Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L., Langer, R. “Controlled Delivery Systems for proteins based on poly(Lactic/Glycolic Acid) Microspheres”, Pharm. Res.; 8: 713-720, 1991.
Langer, R. “Polymer implants for drug delivery in the brain”, J. Cont. Rel.; 16: 53-60, 1991.
Mikos, A., Mathiowitz, E., Langer, R. Peppas, N. “The interaction of Polymer microspheres with Mucin Gels as a Means of characterizing polymer retention on Mucus”, J. Colloid Inter. Sci.; 143: 366-373, 1991.
Moses, M., Langer, R. “Inhibitors of Angiogenesis”, Bio/Technology; 9: 630-634, 1991.
Ron, E., Langer, R. “Erodible systems”, Treatise on Cont. Drug Del.; pp. 199-224, 1991.
Edelman, E., Mathiowitz, E., Langer, R., Klagsburn, M. “Controlled and Modulated Release of Basic Fibroblast Growth Factor”, Biomaterials; 12: 619-626, 1991.
Sluzky, V. Tamada, J.A., Klibanov, A., Langer, R. “Kinetics of Insulin Aggregation in Aqueous Solutions upon Agitation in the Presence of Hydrophobic Surfaces”, PNAS; 88: 9377-9381, 1991.
Madrid, Y., Brem, H., Langer, R. “New Directions in the Delivery of Drugs and Other Substances to the Central Nervous System”, Adv. in Pharm.; 22: 299-324, 1991.
Wheatley, M., Chang, M., Park, E., Langer, R. “Coated Alginate Microspheres: Factors Influencing the Controlled Delivery of Macromolecules”, J. Appl. Poly. Sci.; 43: 2123-2135, 1991.
Wintermantel, E., Cima, L., Schloo, B., Langer, R. “Angiopolarity: a new design parameter for cell transplantation devices and its application to degradable systems”, ASAIO Trans.; 37: m334-m336, 1991.
Zimmerman, J., Langer, R., Cooney, C. “The release of heparinase from the Periplasmic space of flavobacterium heparinum by Three Step Osmotic Shock”, Appl. Biochem. and Biotech.; 30: 137-148, 1991.
Moses, M., Langer, R. “A metalloproteinase Inhibitor as an Inhibitor of Neovascularization”, J. Cell. Biochem; 47: 230-235, 1991.
Langer, L., Brem, H., Langer, R. “New technologies for fighting Brain Disease”, Tech. Rev.; 94: 62-71, 1991.
Liu, R., Klibanov, A., Langer, R. “Moisture-Induced Aggregation of Lyophilized Proteins in the Solid State”, Biotech. Bioeng.; 37: 177-184, 1991.
Langer, R., Kost, J. “Real Time Response polymeric delivery systems in Temporal Control of Drug Delivery”, Annals of the New York Academy of Sciences; 618: 330-334, 1991.
Cohen, S., Bernstein, H., Hewes, C., Chow, M., Langer, R. “The Pharmacokinetics of and humoral responses to antigen delivered by microencapsulated Liposomes”, PNAS; 10440-10444, 1991.
Vacanti, C., Langer, R., Schloo, B., Vacanti, J. “Synthetic Polymers Seeded with Chondrocytes Provide a Template for New Cartilage Formation”, J. Plastic Surg.; 88: 753-759, 1991.
Tudor, A., Church, S., Domb, A., Hendra, P., Langer, R., Celia, C., Davies, M. “The Application of Fourier-Transform Raman Spectroscopy to the Analysis of Poly(Anhydride) Homo and Co-Polymers”, Spectrochimica Act.; 47A: 1335- 1343, 1991.
Langer, R. Drug delivery systems”Drug delivery systems”, Mat. Res. Bulletin; Materials Research Society, 1: 47-49, 1991.
Cima, L., Langer, R., Vacanti, J. “Polymers for tissue and Organ culture”, J. Bioactive and Compatible Poly.; 6: 232-239, 1991.
Domb, A., Mathiowitz, E., Ron, E., Giannos, S., Langer, R. “Polyanhydrides IV: Unsaturated and cross- Linked Polyanhydrides”, J. Poly. Sci.; 29: 571-579, 1991.
Volkin, D., Staubli, A., Langer, R., Klibanov, A. “Enzyme Thermoinactivation in AnLydrous Organic Solvents”, Biotech. Bioeng.; 37: 843-853, 1991.
Freed, L., Vunjak-Novakovic, G., Obradovic, B., Drinker, P., Langer, R. “A bioreactor for blood detoxification: fluid dynamic and ex vivo modeling Studies”, Macroscopic & Microscopic Heat & Mass Transfer in Biomed. Eng.; 55-66, 1991.